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This process is further amplified by the lipid-rich TME, where CD36 upregulation on CD8 T cells is correlated with increased expression of the exhaustion markers PD-1, TIM-3, and LAG-3 [53]

The results from the study on the prodrugs impact on tumor growth in A549 xenografts show that it is more effective at inhibiting tumor growth in vivo than the unmodified 5-FU compound (Figure 5C)

Like other organs, the nervous system is composed of specific cell types with distinct metabolic needs and characteristics, which can lead to mitochondrial heterogeneity (Rangaraju et al., 2019

These interwoven networks highlight the reciprocal relationship between obesity, endocrine dysfunction, and reproductive health, underscoring the necessity for focused therapies to alleviate these impacts

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